一、基本信息
宋蔚，副教授，硕士生导师，药学系主任
研究领域：靶向抗肿瘤药物开发、药物分析
电子邮件：belinde_83@163.com
二、教育背景及工作经历
2016.01-至今 悟空体育悟空体育，副教授，硕士生导师
2018.03–2019.08 University of Notre Dame，博士后
2009.09–2015.05 华中科技大学& University of Notre Dame，生物制药工程专业，联合培养博士
2005.09–2008.07 悟空体育，微生物与生化药学专业，医学硕士
2001.09–2005.07 悟空体育，生物科学专业，理学学士
三、研究方向
天然抗肿瘤药物的靶向结构修饰，靶向医药原料开发，药物分析
四、科研项目
1. 国家自然科学基金（81903484）：基于NQO1激活的雷公藤甲素全新衍生物的合成及抗肝癌活性研究，2020.01–2023.12，主持
2. 湖北省教育厅青人才项目（Q20171007），创伤性脑损伤后ADAM10对Tau蛋白的降解作用，2015.01–2016.12，主持
五、代表性论文
1. Yuhan Chen , Meiyu Liang , Wen Li , Zhiming Yang , Xingting Yan , Liuying Wu , Qin Yua,Yubai Chen , Yong Chen , Yan Xu, Wei Song, Zhihong Peng， Water-soluble and predictable-release triptolide prodrugs block bleomycin-induced pulmonary fibrosis in mice，European Journal of Medicinal Chemistry，279 (2024) 116839 （通讯作者）
2. Liu L*, Song W, Zeng J, Peng Z*. Evaluating a Specific Dual ROCK Inhibitor against Bleomycin-Induced Idiopathic Pulmonary Fibrosis in Rats. ACS Pharmacol. Transl. Sci. 2022, https://doi.org/10.1021/acsptsci.2c00149.（并列第一作者）
3. Kang Fu, Xueyao Zheng, Yuhan Chen, Liuying Wu, Zhiming,Yang, Xu Chen, Wei Song*.Role of matrix metalloproteinases in diabetic foot ulcers: potential therapeutic targets. Frontiers in Pharmacology. DOI 10.3389/fphar.2022.1050630
4. 宋蔚， 吴柳莹， 张文婷， 胡晓艺， 杜晓月， 王梦雅， 郑雪瑶， 左佩文， 彭志红*. 基于 NANO-LC-MS/MS和生物信息学的抗特发性肺纤维化靶点的筛选与验证。中国药学杂志, 2022.已接受。
5. Meilin Liu, Wei Song, Xi Du, Jingtian Su, Kang Dong, Yong Chen, and Zhihong Peng AN NQO1-Selective Activated Prodrug of Triptolide: Synthesis and Antihepatocellular Carcinoma Activity Evaluation. ACS Med. Chem. Lett. 2018, 9, 1253-1257
6. Song W, Liu M, Wu J, Zhai H, Chen Y, Peng Z. Preclinical Pharmacokinetics of Triptolide: A Potential Antitumor Drug. Curr Drug Metab. 2019;20(2):147-154. doi: 10.2174/1389200219666180816141506. PMID: 30112986.
7. Song, W., Wu, J., Yu, L., Peng, Z. Evaluation of the pharmacokinetics and hepatoprotective effects of phillygenin in mouse. BioMed research international, 2018. https://doi.org/10.1155/2018/7964318.
8. Wei Song, Zhihong Peng, Major Gooyit, Mark A. Suckow, Valerie A. Schroeder, William R. Wolter, Mijoon Lee, Masahiro Ikejiri, Jiankun Cui, Zezong Gu, and Mayland Chang. Water-soluble MMP-9 inhibitor prodrug generates active metabolites that cross the blood-brain barrier. ACS Chem. Neurosci., 2013, 4 (8), 1168–1173.
9. Wei Song, Mingzhang Ao，Yue Shi, Lingfang Yuan, Xinxia Yuan, Longjiang Yu. Interaction between Phillygenin and Human Serum Albumin based on Spectroscopic and olecular docking. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2012 Jan;85(1):120-6
10.Wei Song, Zhihong Peng, Baoying Ge, Fengmei Han, Yong Chen. Identification of metabolites of lobeline in the rat urine by liquid chromatographytandem mass spectrometry. International Journal of Mass Spectrometry. 2008, 269(1-2):131-137.
11. Major Gooyit, Wei Song, Kiran V. Mahasenan, Katerina Lichtenwalter, Mark A. Suckow, Valerie A. Schroeder, William R. Wolter, Shahriar Mobashery, and Mayland Chang. O-Phenyl Carbamate and Phenyl Urea Thiiranes as Selective Matrix Metalloproteinase-2 Inhibitors that Cross the Blood-Brain Barrier. Journal of Medicinal Chemistry, DOI: 10.1021/jm401217d.
12. Yong Chen, Wei Song, Zhi H. Peng, Bao Y. Ge, Feng M. Han. Identification of metabolites of tectoridin in vivo and in vitro by liquid chromatography - tandem mass spectrometry. Journal of Pharmacy and Pharmacology. 2008, 60 (6): 709-716.
13. Zhihong Peng, Wei Song, Fengmei Han, Huaixia Chen, Mingming Zhu, Yong Chen. Chromatographic Tandam Mass Spectrometric Detection of Papaverine and Its Major Metabolites in Rat Urine. International Journal of Mass Spectrometry. 2007, 266 (1-3): 114-121.
14. Peng Zhihong, Song Wei, Han Fengmei, Chen Yong. In vivo and in vitro study of papaverine and its major metabolites. Yao Xue Xue Bao. 2009, 44(1):95-100.
15. F.M. Han, Z.H. Peng, W. Song, H.M. Zhang, M.M. Zhu, Y. Chen. Identification of Dauricine and Its Metabolites in Rat Urine by Liquid Chromatography-Tandem Mass Spectrometry. Journal of Chromatogr B. 2007, 854 (1-2): 1-7
16. Y. Chen, Z. H. Peng, W. Song, M. M. Zhu, and F. M. Han. Chromatographic Tandem Mass Spectrometric Detection of Physostigmine and its Major Metabolites in Rat Urine. Analytical letters. 2007, 40(16-18): 3256-3266.
六、专利：
1. 彭志红，刘媚琳，杨雁羽，杜茜，宋蔚，陈勇. 一种水溶性雷公藤甲素衍生物及其制备方法和用途。授权专利号：ZL 201910325154.0 。
2. 宋蔚，彭志红，刘媚琳，张雪珂，杜茜，陈勇。一种雷公藤甲素衍生物及其制备方法和用途。授权专利号：ZL201710358992.9.
3. 彭志红;宋蔚;陈雨涵;杨智明;李雯;梁美玉;范力;吴怡媛;陈勇。水溶性雷公藤甲素前药化合物及其合成方法和应用。授权专利号：ZL 2023 1 1655754.6
